rev. June 12, 2017
MONOCLONAL ANTIBODY

Anti-GPI-PLD(38A1)

Catalog No. LF-MA0156 

Background : GPI-PLD
(glycosylphosphatidylinositol specific Species cross reactivity
(Anti-Glycosylphosphatidylinositol-specific phospholipase D)
-
phospholipase D), a 815-amino acid protein,
is expressed in numerous tissues and cells
and specifically cleaves GPI-anchored
proteins. Liver has the highest level of GPIPLD expression and is the primary organ
contributing to GPI-PLD in the serum. GPIPLD is abundant in serum in which it
i i h li i AI d AIV
Human Mouse Rat
+ NT NT
Species cross reactivity
M.W.(kDa) 1 2
associates with apolipoproteins AI and AIV.
Increased serum GPI-PLD is associated with
insulin resistance and elevated serum
triglycerides. Many surface proteins are
attached to eukaryotic cell membranes via
glycosylphosphatidylinositol (GPI) anchors
that are covalently bound to the C-terminus
of the protein and cleavage of the GPI

Background
moiety by GPI-PLD, only enzyme known
that cleavage GPI anchor, may represent a
means of regulating attachment of these
proteins to the cell surface, or alternatively,
their release into the extracellular
environment.
Immunogen : Protein purified from Human
plasma Applications :
32.5
Immunoblot Analysis of human plasma protein
Lane 1 : GPI-PLD protein isolated from human plasma
Lane 2 : Human plasma
plasma
Host : Mouse
Clone number : 38A1
Isotype : IgG1, k
Size : 100㎍ (1㎎/㎖)
Composition : PBS containing 50% glycerol
Positive control : Human plasma
Applications :
ELISA
Western blotting (1:500)
Background Reference :
1) Chalasani N et al, J Clin Endocrinol Metab. 2006;
vol.91(6): pp.2279-85.
2) MANN KJ et al, Biochem. J. 2004; vol.378: pp.641-
8.
Science Building C, Rm 105, Ewha Univ. 11-1, Daehyundong, Seodaemun-gu, Seoul, 120-750, Korea
FOR RESEARCH PURPOSE ONLY
NOT FOR DIAGNOSTIC OR THERAPEUTIC USE
Positive control : Human plasma
Storage : Store for 1 year at –20℃ from date
of shipment
3) Gregory P et al, Bone. 2005; vol.37(2): pp.139-47.
4) Raikwar NS et al, Am J Physiol Endocrinol Metab.
2006; vol.290(3): pp.E463-70.